U.S. Post Office, and Courthouse Owensboro
- Address: 423 Frederica Street Owensboro, KY 42301
- Stories: 4
- Year Built: 1911
- Architect: James Knox Taylor
- Description: The Federal Building, U.S. Post Office and Courthouse in Owensboro, Kentucky, is a three-story Renaissance Revival building. Resting on a granite base, the rusticated limestone first floor level supports two upper stories clad with buff brick and limestone trim.
- Facility Type: Single Building
- Primary Usage: Office
